The DeSoto House Hotel is the oldest operating hotel in Illinois located on famous Main Street in Galena, IL. The DeSoto House Hotel opened its doors in 1855 and continues to welcome guests with hospitality, charm and history, awarding us the title of "'Illinois' Oldest Operating Hotel." Throughout the years we have welcomed such memorable guests as Abraham Lincoln, William Jennings Bryan, and serving as the presidential campaign headquarters for Ulysses S. Grant just to name a few. Nestled in the heart of Downtown Galena, the DeSoto House puts you in the midst of fine antique shops, restaurants, boutiques, historical points of interest and picturesque 1800's architecture. Galena's rich history comes alive the minute you step into our Lobby. Our staircase and ballroom are reminiscent of grand and gala events that took place throughout the past 156 years. Today, the DeSoto House welcomes guests with genuine warmth and hospitality and is dedicated to helping our guests enjoy our history!